Endometriosis at the metal–microbe–immune interface
How low-nickel dietary responses, red meat and heme iron, microbial signals, and nutritional immunity define a research program in endometriosis.
Microbial Metallomics
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Browse connected writing by metal and research theme. These collections organize what the site covers; a shared topic is not evidence of a causal relationship.
Iron
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Transferrin, ferritin and the race to recycle heme
How transferrin, ferritin, haptoglobin and hemopexin route iron, protect tissue and face microbial piracy—and which experiments distinguish those effects.
Silymarin, metal binding and the liver
Milk-thistle chemistry can bind or reduce metals, but nickel protection, lead measurements and human liver trials answer different mechanistic questions.
Lactoferrin: iron withholding and microbial countermeasures
How lactoferrin withholds iron, disrupts microbial behavior, and faces bacterial countermeasures—and what oral human studies actually establish.
Hepcidin and ferroportin: iron redistribution in host defense
How hepcidin controls ferroportin, redistributes iron during inflammation, and creates different tradeoffs for microbes and red-cell production.
Glutathione, metals and the mitochondrial reserve
How glutathione supports enzymes, binds metals and enters mitochondria—and what drug metabolism does and does not establish about shared cellular reserve.
Dementia’s regional metal signatures
Dementia brain-metal signatures reveal regional copper loss and iron gain. A critical review connects these patterns to testable microbial-metallomics research.
Alzheimer’s disease: copper depletion and regional metal contrasts
Alzheimer’s brain copper loss and regional iron and zinc changes reveal a spatial disease signature—and define experiments for microbial metallomics.
Iron Fortification and the Kenyan Infant Gut Microbiome
A full review of Jaeggi et al. (Gut 2015): iron-fortified porridge increased pathogenic E. coli and enterobacteria, cut bifidobacteria, and inflamed the gut in Kenyan infants.
The Metal–Microbiome–Disease Axis: Who Gets the Metal?
Metals change microbial ecology; microbes change metal chemistry; inflammation changes local metal access. Follow the mechanisms connecting exposure, nutritional immunity, and disease.
Metals, the Microbiome, and Parkinson's: A Gut-First Pathway to Neurodegeneration
How heavy-metal exposure may reshape the gut microbiome and feed gut-first alpha-synuclein pathology in Parkinson's disease - a metallomic-microbiome view.
Feeding the Enemy: How Dietary Iron Reshapes the Gut Microbiome and Raises Enteric Infection Risk
Unabsorbed iron can alter the gut microbiome and intestinal inflammation. Human trials show that effects on diarrhea vary by setting and formulation.
From Dysbiosis to Dyshomeostasis: Reframing Parkinson's Through a Metallomic–Microbiome Lens
A metallomics framework reframes Parkinson's as metal dyshomeostasis: iron, manganese, copper, zinc and nickel dysregulation drives dysbiosis and neuron loss.
The MC1R–Parkinson's Link May Be a Metallomic Story, Not a Cosmetic One
A hypothesis linking MC1R red-hair variants to Parkinson's risk via melanin-metal chemistry: how copper, zinc, and iron shape neuromelanin's redox buffering.
Lactoferrin vs. Ferrous Sulfate Through a Metallomics Lens
Meta-analyses show oral lactoferrin can match or outperform ferrous sulfate for iron repletion, lowering IL-6 and hepcidin with fewer gut side effects.
Lactobacillus plantarum 299v and Oral Iron Therapy Tolerance
A randomized trial shows the probiotic Lactobacillus plantarum 299v reduces oral iron side effects and improves iron status in iron-deficiency anemia patients.
Iron- and Zinc-Biofortified Foods and the Gut Microbiota
Systematic review of iron/zinc-biofortified bean and wheat diets in the Gallus gallus model: staples raised SCFA-producing Lactobacillus and cut enteric pathogens.
Iron Supplements and the Gut Microbiome in Reproductive-Age Women: A Randomized Controlled Trial
A 21-day randomized placebo-controlled trial found ferrous fumarate did not significantly alter fecal microbiome composition in Australian reproductive-age women.
Iron Fortification, the Infant Gut Microbiome, and Diarrhea Risk
Iron fortification shifts the infant gut microbiome toward enterobacteria and pathogenic E. coli, cutting protective bifidobacteria and raising diarrhea risk.
Prebiotics Blunt the Gut Cost of Iron-Fortified Cereal in Kenyan Infants
In a Kenyan infant RCT, adding prebiotic GOS/FOS to iron-fortified cereal raised iron absorption 60% and reduced gut inflammation, pathogens, and dysbiosis.
Nutritional Immunity and Trace Metals in Infection
How the host uses iron, zinc, manganese and copper handling as nutritional immunity to starve or poison pathogens, plus metal-based therapeutic strategies.
Metal Availability and Immune Function During Infection
How zinc, iron, manganese, and copper availability shapes neutrophil and macrophage function during infection through nutritional immunity, calprotectin, and phagosomal metal handling.
Iron Chelation Therapy in Transfusion-Dependent Thalassemia
Clinical review of deferoxamine, deferiprone, and deferasirox for transfusion iron overload in thalassemia, covering cardiac and hepatic iron outcomes measured by MRI T2*.
Gallium as an Iron Mimic: Disrupting Pseudomonas Iron Metabolism in Cystic Fibrosis
Gallium substitutes for iron to sabotage Pseudomonas aeruginosa iron metabolism. A Phase 1 CF trial (Goss et al., Sci Transl Med 2018) found IV gallium improved lung function.
Proteome-Scale Mapping of Iron-Binding Proteins in Bread Wheat
A proteome-wide scan of bread wheat mapped ~600 iron-binding proteins with Fe(II)/Fe(III) sites coordinated by His, Glu, Asp and Cys, aiding metallomics.
Colorectal cancer: mapping metals, cells, and microbial questions
Colorectal cancer metal maps reveal distinct copper and iron neighborhoods. What they measured, and how to test microbial access, host response and disease.
The Iron Metalloproteome of Pseudomonas aeruginosa Under Oxic and Anoxic Conditions
Native metalloproteomics maps how Pseudomonas aeruginosa partitions iron across four protein complexes, with denitrification raising iron demand in anoxia.
Iron-Sulfur Clusters and Oxygen in Human Disease
How iron-sulfur (Fe-S) cluster biogenesis and oxygen shape human disease: NFS1 in lung cancer, hyperoxia injury, and hypoxia therapy for Friedreich ataxia.